Detailed information of TA system TA208607

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 1551088..1551286
• Replicon: chromosome
• Accession: NZ_CP077922
• Organism: Staphylococcus aureus strain 202

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU538_RS07760
• Protein ID: WP_001802298.1
• Coordinates: 1551182..1551286 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1551088..1551126 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU538_RS07735	1547208..1547873	-	666	WP_001024099.1	SDR family oxidoreductase	-
KU538_RS07740	1548025..1548345	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU538_RS07745	1548347..1549327	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
KU538_RS07750	1549593..1550684	+	1092	WP_000495673.1	hypothetical protein	-
KU538_RS07755	1551068..1551142	+	75	Protein_1500	hypothetical protein	-
-	1551088..1551126	+	39	-	-	Antitoxin
KU538_RS07760	1551182..1551286	-	105	WP_001802298.1	hypothetical protein	Toxin
KU538_RS07765	1551966..1552124	+	159	WP_001792784.1	hypothetical protein	-
KU538_RS07770	1552560..1552652	+	93	WP_000220902.1	hypothetical protein	-
KU538_RS07775	1552782..1553639	-	858	WP_000370942.1	HAD family hydrolase	-
KU538_RS07780	1553707..1554489	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
KU538_RS07785	1554779..1555387	-	609	WP_000101715.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208607 WP_001802298.1 NZ_CP077922:c1551286-1551182 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208607 NZ_CP103687:349414-349761 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT208607 NZ_CP077922:1551088-1551126 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin