Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1400062..1400485 Replicon chromosome
Accession NZ_CP077922
Organism Staphylococcus aureus strain 202

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag KU538_RS06935 Protein ID WP_001065091.1
Coordinates 1400234..1400485 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag KU538_RS06930 Protein ID WP_000028422.1
Coordinates 1400062..1400244 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU538_RS06885 (1395448) 1395448..1397109 - 1662 WP_000625088.1 terminase large subunit -
KU538_RS06890 (1397106) 1397106..1397450 - 345 WP_000402904.1 hypothetical protein -
KU538_RS06895 (1397580) 1397580..1397879 - 300 WP_000988336.1 HNH endonuclease -
KU538_RS06900 (1398111) 1398111..1398527 - 417 WP_000590122.1 hypothetical protein -
KU538_RS06905 (1398555) 1398555..1398755 - 201 WP_000265043.1 DUF1514 family protein -
KU538_RS06910 (1398755) 1398755..1398904 - 150 WP_000595265.1 transcriptional activator RinB -
KU538_RS06915 (1398901) 1398901..1399287 - 387 WP_000592207.1 hypothetical protein -
KU538_RS06920 (1399284) 1399284..1399490 - 207 WP_000195803.1 DUF1381 domain-containing protein -
KU538_RS06925 (1399527) 1399527..1400069 - 543 WP_000185660.1 dUTP pyrophosphatase -
KU538_RS06930 (1400062) 1400062..1400244 - 183 WP_000028422.1 hypothetical protein Antitoxin
KU538_RS06935 (1400234) 1400234..1400485 - 252 WP_001065091.1 DUF1024 family protein Toxin
KU538_RS06940 (1400478) 1400478..1400645 - 168 WP_001624242.1 hypothetical protein -
KU538_RS06945 (1400657) 1400657..1400899 - 243 WP_000131366.1 SAV1978 family virulence-associated passenger protein -
KU538_RS06950 (1400903) 1400903..1401271 - 369 WP_000101274.1 SA1788 family PVL leukocidin-associated protein -
KU538_RS06955 (1401284) 1401284..1401688 - 405 WP_000401960.1 RusA family crossover junction endodeoxyribonuclease -
KU538_RS06960 (1401697) 1401697..1401915 - 219 WP_000338530.1 hypothetical protein -
KU538_RS06965 (1401922) 1401922..1402806 - 885 WP_000148316.1 DnaD domain protein -
KU538_RS06970 (1402836) 1402836..1403306 - 471 WP_000934764.1 single-stranded DNA-binding protein -
KU538_RS06975 (1403307) 1403307..1403924 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
KU538_RS06980 (1404005) 1404005..1404925 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / hlb / groEL 1374652..1425622 50970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T208604 WP_001065091.1 NZ_CP077922:c1400485-1400234 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T208604 NZ_CP103684:c274216-273758 [Enterobacter hormaechei]
GTGATCCTGTATCGGATGACCAAGACCCGCTATATTACGACTGCATGGTCGGGATTAGGTGCGAAAGAAGCGGGAGGCCG
CTGGAACAGTGTCGGCACAGCACTTGTCTATCTGTCCGAGACGGCCTCTCTGACCATGCTGGAGACGCTGGTGCATATCA
ATGCCCCGCAGCTTCTGGACGCTTACACGCTGCTGAGCATTGATGTCCCGGATGACCAGATCCAGGCCTTTGACTTGAAC
CTGCTGCCGCCGGGCTGGGCAAGTGAAGATGCGCCCGCAGAACTTGCCCTGTATGGCGATAACTGGGCTGAAAGTGGCTC
TTCTGTTGCCCTGCGTATTCCCAGTGCATTATCTCCGGTGGAGTTTAACTACCTTTTAAATCCGGCTCATCCGGCGATTT
TTGATCTGATGAAAACCGTCCAGAAAATTCCTTACCAGTACGACACACGGCTGAAATAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT208604 WP_000028422.1 NZ_CP077922:c1400244-1400062 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT208604 NZ_CP103684:c274659-274213 [Enterobacter hormaechei]
ATGACTATGAAAGTTTTTTCTCCAGATTTATCCAAAATGAACCCGCACGGCTTATGGCAGGTGGTGGGTCTGGATAATGA
CGGCATTGCGCTGATGGACAAAATTAGCCACGGACTGGAAGGTAAAGTCGCTCATTCCATTTCTGAATGGGCGAACATCA
CGCCGTCGGAACTGCGCAAAATGTCCGGCATTCCGAACACCACCTTCAATCGCAGCGTAAAAGCCCGTTTCACTGCGGAT
CAGAGCGAACGTCTGGTGCGTATTATTCGCGTCATTGAACGGGCTGTAGAGCTGTTCGAAGGCGACAAAGAGGCAGCACA
GAAATGGATGAACGAGCCAAACCGTGGCTTGAGCTGGAAGACTCCGGCAGATGTTGTCTCTTCGGAAACCGGCGCACTCG
AAGTGATGCGCCTGATCACCCGTATTGAACACGGAGTCTATTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References