Detailed information of TA system TA208590

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2518900..2519162
• Replicon: chromosome
• Accession: NZ_CP077921
• Organism: Staphylococcus aureus strain 276

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU530_RS12345
• Protein ID: WP_001802298.1
• Coordinates: 2518900..2519004 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2518999..2519162 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU530_RS12330 (KU530_12285)	2515696..2516478	+	783	WP_000908174.1	ABC transporter ATP-binding protein	-
KU530_RS12335 (KU530_12290)	2516546..2517403	+	858	WP_000370931.1	HAD family hydrolase	-
KU530_RS12340 (KU530_12295)	2518062..2518220	-	159	WP_001792784.1	hypothetical protein	-
KU530_RS12345 (KU530_12300)	2518900..2519004	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2518999..2519162	-	164	-	-	Antitoxin
KU530_RS12355 (KU530_12305)	2519812..2521458	+	1647	WP_000277718.1	IS1182 family transposase	-
KU530_RS12360 (KU530_12310)	2521487..2522578	-	1092	WP_000495672.1	hypothetical protein	-
KU530_RS13480	2522704..2522838	+	135	WP_263973923.1	hypothetical protein	-
KU530_RS12365 (KU530_12315)	2522844..2523824	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
KU530_RS12370 (KU530_12320)	2523826..2524146	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2519812..2521458	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208590 WP_001802298.1 NZ_CP077921:2518900-2519004 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208590 NZ_CP103681:c58386-57970 [Enterobacter hormaechei]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT208590 NZ_CP077921:c2519162-2518999 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin