Detailed information of TA system TA208587

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2238916..2239100
• Replicon: chromosome
• Accession: NZ_CP077921
• Organism: Staphylococcus aureus strain 276

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU530_RS10875
• Protein ID: WP_000482647.1
• Coordinates: 2238916..2239023 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2239040..2239100 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU530_RS10850 (KU530_10810)	2234288..2234761	+	474	WP_000456492.1	GyrI-like domain-containing protein	-
KU530_RS10855 (KU530_10815)	2234884..2236095	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU530_RS10860 (KU530_10820)	2236277..2236936	-	660	WP_000831295.1	hypothetical protein	-
KU530_RS10865 (KU530_10825)	2236996..2238138	-	1143	WP_001176863.1	glycerate kinase	-
KU530_RS10870 (KU530_10830)	2238396..2238782	+	387	WP_000779360.1	flippase GtxA	-
KU530_RS10875 (KU530_10835)	2238916..2239023	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2239040..2239100	-	61	-	-	Antitoxin
KU530_RS10880 (KU530_10840)	2239727..2241490	+	1764	WP_001064836.1	ABC transporter ATP-binding protein	-
KU530_RS10885 (KU530_10845)	2241515..2243248	+	1734	WP_000486496.1	ABC transporter ATP-binding protein	-
KU530_RS10890 (KU530_10850)	2243479..2243646	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208587 WP_000482647.1 NZ_CP077921:2238916-2239023 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208587 NZ_CP103679:c4674255-4673884 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT208587 NZ_CP077921:c2239100-2239040 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin