Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2207030..2207553 Replicon chromosome
Accession NZ_CP077921
Organism Staphylococcus aureus strain 276

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag KU530_RS10735 Protein ID WP_000074045.1
Coordinates 2207287..2207553 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag KU530_RS10730 Protein ID WP_000587619.1
Coordinates 2207030..2207287 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU530_RS10710 (KU530_10670) 2202110..2203303 + 1194 WP_000675406.1 MFS transporter -
KU530_RS10715 (KU530_10675) 2203527..2204276 - 750 WP_000072464.1 CPBP family lipoprotein N-acylation protein LnsB -
KU530_RS10720 (KU530_10680) 2204471..2206048 + 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
KU530_RS10725 (KU530_10685) 2206216..2206671 - 456 WP_000732082.1 DUF1307 domain-containing protein -
KU530_RS10730 (KU530_10690) 2207030..2207287 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU530_RS10735 (KU530_10695) 2207287..2207553 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
KU530_RS10740 (KU530_10700) 2207909..2208985 + 1077 WP_001076673.1 M42 family metallopeptidase -
KU530_RS10745 (KU530_10705) 2209233..2209895 + 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
KU530_RS10750 (KU530_10710) 2209888..2210664 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KU530_RS10755 (KU530_10715) 2211060..2212247 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T208586 WP_000074045.1 NZ_CP077921:2207287-2207553 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T208586 NZ_CP103679:c4548983-4548798 [Enterobacter hormaechei]
GTGAAAAGTGCGGATATCATTGCTGTTCTGGTTAGCCATGGCTGGAAATGTGTAAGAACGAAGGGAAGCCATCATCAGTT
TCGCCATCCAGTGCAAAAAGGGTTGGTAACCGTTCCGCATCCTAAAAAGGACATTAAACCGGGCACTCTCGCACAGATCT
GGCGACAGGCGGGCATTAAACACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT208586 WP_000587619.1 NZ_CP077921:2207030-2207287 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208586 NZ_CP103679:c4548783-4548379 [Enterobacter hormaechei]
ATGTTTTATCCGGCTTACATTCATTCTGATTCCGACGGTAGCGCCAGCGGTTTCTTCCCCGACGTTCCGGGATGTTTTTT
TGCGGGGGATTCACTTGATGACGCTTTTCAGGATGCACGTGATGCGCTCACGGCGCACTTCGAAGCGCTGTTTGAAATGG
ATGAAGCATTGCCTCTCCCGGGTAGTGTCGAAGTGCACCTTGAAAATCAACCTGACGACTTCACAGGCGGGCAATGGTTG
CTGGTGGATATTAATATGAAGCAATTCGACGGCAGAGCCGAACGCATCAACATCACAATGCCTCGACGTTTGCTGGTGAA
GATTGATTCCTTTGTCAGCGAGCATCCTCAATTCGGCAATCGAAGCGCATTTCTGGCCGAGGCAGCACGTCGCGTGCTGC
CGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References