Detailed information of TA system TA208577

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1823139..1823402
• Replicon: chromosome
• Accession: NZ_CP077920
• Organism: Staphylococcus aureus strain 277

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU525_RS08955
• Protein ID: WP_001802298.1
• Coordinates: 1823139..1823243 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1823238..1823402 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU525_RS08925	1818523..1819305	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
KU525_RS08930	1819373..1820230	+	858	WP_000370924.1	HAD family hydrolase	-
KU525_RS08935	1820462..1820646	-	185	Protein_1754	exotoxin	-
KU525_RS08940	1820935..1821027	-	93	WP_001790138.1	hypothetical protein	-
KU525_RS08945	1821316..1822452	+	1137	WP_000115564.1	SAP domain-containing protein	-
KU525_RS08950	1822495..1822978	+	484	Protein_1757	recombinase family protein	-
KU525_RS08955	1823139..1823243	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1823238..1823402	-	165	-	-	Antitoxin
KU525_RS08965	1823686..1824777	-	1092	WP_000495683.1	hypothetical protein	-
KU525_RS08970	1825043..1826023	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU525_RS08975	1826025..1826345	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU525_RS08980	1826497..1827162	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208577 WP_001802298.1 NZ_CP077920:1823139-1823243 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208577 NZ_CP103679:c1156363-1156145 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACTCTCGAACGTGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAGC
TGACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTGTGGAAATTTGTTCGTTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT208577 NZ_CP077920:c1823402-1823238 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin