Detailed information of TA system TA208574

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1538037..1538221
• Replicon: chromosome
• Accession: NZ_CP077920
• Organism: Staphylococcus aureus strain 277

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: KU525_RS07470
• Protein ID: WP_000482652.1
• Coordinates: 1538037..1538144 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1538161..1538221 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU525_RS07445	1533399..1533872	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
KU525_RS07450	1533995..1535206	-	1212	WP_001191922.1	multidrug effflux MFS transporter	-
KU525_RS07455	1535388..1536047	-	660	WP_000831298.1	membrane protein	-
KU525_RS07460	1536107..1537249	-	1143	WP_001176863.1	glycerate kinase	-
KU525_RS07465	1537517..1537903	+	387	WP_000779357.1	flippase GtxA	-
KU525_RS07470	1538037..1538144	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1538161..1538221	-	61	-	-	Antitoxin
KU525_RS07475	1538847..1540610	+	1764	WP_001064837.1	ABC transporter ATP-binding protein	-
KU525_RS07480	1540635..1542368	+	1734	WP_049307645.1	ABC transporter ATP-binding protein	-
KU525_RS07485	1542599..1542766	+	168	WP_001789205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208574 WP_000482652.1 NZ_CP077920:1538037-1538144 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208574 NZ_CP103676:c5239432-5239049 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208574 NZ_CP077920:c1538221-1538161 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin