Detailed information of TA system TA208570

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1408545..1408883
• Replicon: chromosome
• Accession: NZ_CP077920
• Organism: Staphylococcus aureus strain 277

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU525_RS06895
• Protein ID: WP_011447039.1
• Coordinates: 1408545..1408721 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1408709..1408883 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU525_RS06875	1403780..1407565	+	3786	WP_000582165.1	phage tail spike protein	-
KU525_RS06880	1407555..1407707	+	153	WP_001153681.1	hypothetical protein	-
KU525_RS06885	1407754..1408041	+	288	WP_001040261.1	hypothetical protein	-
KU525_RS06890	1408099..1408395	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU525_RS06895	1408545..1408721	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1408709..1408883	-	175	-	-	Antitoxin
KU525_RS06905	1408933..1409187	+	255	WP_000611512.1	phage holin	-
KU525_RS06910	1409199..1409954	+	756	WP_064131634.1	CHAP domain-containing protein	-
KU525_RS06915	1410145..1410636	+	492	WP_000919350.1	staphylokinase	-
KU525_RS06920	1411286..1411621	+	336	Protein_1360	SH3 domain-containing protein	-
KU525_RS06925	1411716..1412165	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU525_RS06930	1412850..1413200	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU525_RS06935	1413253..1413513	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1368256..1413200	44944

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208570 WP_011447039.1 NZ_CP077920:1408545-1408721 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208570 NZ_CP103676:c4631712-4631179 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT208570 NZ_CP077920:c1408883-1408709 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin