Detailed information of TA system TA208562

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2443418..2443680
• Replicon: chromosome
• Accession: NZ_CP077919
• Organism: Staphylococcus aureus strain 278

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU514_RS12155
• Protein ID: WP_001802298.1
• Coordinates: 2443418..2443522 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2443517..2443680 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU514_RS12140 (KU514_12070)	2440214..2440996	+	783	WP_000908174.1	ABC transporter ATP-binding protein	-
KU514_RS12145 (KU514_12075)	2441064..2441921	+	858	WP_000370931.1	HAD family hydrolase	-
KU514_RS12150 (KU514_12080)	2442580..2442738	-	159	WP_001792784.1	hypothetical protein	-
KU514_RS12155 (KU514_12085)	2443418..2443522	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2443517..2443680	-	164	-	-	Antitoxin
KU514_RS12165 (KU514_12090)	2444330..2445976	+	1647	WP_000277718.1	IS1182 family transposase	-
KU514_RS12170 (KU514_12095)	2446005..2447096	-	1092	WP_000495672.1	hypothetical protein	-
KU514_RS13825	2447222..2447356	+	135	WP_263973923.1	hypothetical protein	-
KU514_RS12175 (KU514_12100)	2447362..2448342	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
KU514_RS12180 (KU514_12105)	2448344..2448664	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2444330..2445976	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208562 WP_001802298.1 NZ_CP077919:2443418-2443522 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208562 NZ_CP103675:2110-2397 [Enterobacter hormaechei]
ATGACTTATACGGTCAAATTCAGGGATGATGCGCTAAAAGAATGGCATAAACTGGATAAAGCTATTCAACAACAATTTGC
AAAAAAATTAAAGAAATGCTGTGGTAATCCTCATATTCCTTCTGCAAAACTGTGCGGGATAAAAGACTGCTACAAAATAA
AACTACGTGCATCCGGTTTTCGTCTGGTCTATCAAGTAATTGATGATCAATTAATTATCGCTGTAGTTGCTGTGGGTAAA
CGTGAACGCAGTGATGTATACAATCTAGCAAGTGAGCGTATGAGATAG

Antitoxin

Nucleotide

• Length: 164 bp

>AT208562 NZ_CP077919:c2443680-2443517 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin