Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2188410..2188927 Replicon chromosome
Accession NZ_CP077919
Organism Staphylococcus aureus strain 278

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KU514_RS10820 Protein ID WP_000113262.1
Coordinates 2188661..2188927 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU514_RS10815 Protein ID WP_000584499.1
Coordinates 2188410..2188661 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU514_RS10785 (KU514_10720) 2184108..2184827 + 720 WP_000479576.1 amino acid ABC transporter permease -
KU514_RS10790 (KU514_10725) 2184824..2185555 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU514_RS10795 (KU514_10730) 2185652..2186902 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
KU514_RS10800 (KU514_10735) 2187157..2187519 + 363 WP_000819843.1 DUF4467 domain-containing protein -
KU514_RS10805 (KU514_10740) 2187538..2188137 + 600 WP_000162810.1 DsbA family protein -
KU514_RS10810 (KU514_10745) 2188165..2188245 + 81 WP_223197974.1 hypothetical protein -
KU514_RS10815 (KU514_10750) 2188410..2188661 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU514_RS10820 (KU514_10755) 2188661..2188927 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KU514_RS10825 2188962..2189033 + 72 WP_223200558.1 hypothetical protein -
KU514_RS10830 (KU514_10760) 2189221..2190771 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU514_RS10835 (KU514_10765) 2190957..2191424 + 468 WP_000153344.1 SRPBCC domain-containing protein -
KU514_RS10840 (KU514_10770) 2191511..2191693 + 183 WP_000079142.1 hypothetical protein -
KU514_RS10845 (KU514_10775) 2191910..2192734 + 825 WP_225806570.1 formate/nitrite transporter family protein -
KU514_RS10850 (KU514_10780) 2192968..2193504 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T208561 WP_000113262.1 NZ_CP077919:2188661-2188927 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208561 NZ_CP103674:c4589434-4589063 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTGTTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTCACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208561 WP_000584499.1 NZ_CP077919:2188410-2188661 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208561 NZ_CP103674:c4589679-4589437 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References