Detailed information of TA system TA208559

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2163434..2163618
• Replicon: chromosome
• Accession: NZ_CP077919
• Organism: Staphylococcus aureus strain 278

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU514_RS10685
• Protein ID: WP_000482647.1
• Coordinates: 2163434..2163541 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2163558..2163618 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU514_RS10660 (KU514_10595)	2158806..2159279	+	474	WP_000456492.1	GyrI-like domain-containing protein	-
KU514_RS10665 (KU514_10600)	2159402..2160613	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU514_RS10670 (KU514_10605)	2160795..2161454	-	660	WP_000831295.1	hypothetical protein	-
KU514_RS10675 (KU514_10610)	2161514..2162656	-	1143	WP_001176863.1	glycerate kinase	-
KU514_RS10680 (KU514_10615)	2162914..2163300	+	387	WP_000779360.1	flippase GtxA	-
KU514_RS10685 (KU514_10620)	2163434..2163541	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU514_RS10690 (KU514_10625)	2164245..2166008	+	1764	WP_001064836.1	ABC transporter ATP-binding protein	-
KU514_RS10695 (KU514_10630)	2166033..2167766	+	1734	WP_000486496.1	ABC transporter ATP-binding protein	-
KU514_RS10700 (KU514_10635)	2167997..2168164	+	168	WP_001792506.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208559 WP_000482647.1 NZ_CP077919:2163434-2163541 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208559 NZ_CP103674:3568409-3568708 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATCCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208559 NZ_CP077919:c2163618-2163558 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin