Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2131548..2132071 Replicon chromosome
Accession NZ_CP077919
Organism Staphylococcus aureus strain 278

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag KU514_RS10545 Protein ID WP_000074045.1
Coordinates 2131805..2132071 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag KU514_RS10540 Protein ID WP_000587619.1
Coordinates 2131548..2131805 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU514_RS10520 (KU514_10455) 2126628..2127821 + 1194 WP_000675406.1 MFS transporter -
KU514_RS10525 (KU514_10460) 2128045..2128794 - 750 WP_000072464.1 CPBP family lipoprotein N-acylation protein LnsB -
KU514_RS10530 (KU514_10465) 2128989..2130566 + 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
KU514_RS10535 (KU514_10470) 2130734..2131189 - 456 WP_000732082.1 DUF1307 domain-containing protein -
KU514_RS10540 (KU514_10475) 2131548..2131805 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU514_RS10545 (KU514_10480) 2131805..2132071 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
KU514_RS10550 (KU514_10485) 2132427..2133503 + 1077 WP_001076673.1 M42 family metallopeptidase -
KU514_RS10555 (KU514_10490) 2133751..2134413 + 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
KU514_RS10560 (KU514_10495) 2134406..2135182 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KU514_RS10565 (KU514_10500) 2135578..2136765 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T208558 WP_000074045.1 NZ_CP077919:2131805-2132071 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T208558 NZ_CP103674:2812603-2812782 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT208558 WP_000587619.1 NZ_CP077919:2131548-2131805 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208558 NZ_CP103674:2812804-2813214 [Enterobacter hormaechei]
ATGTTGTACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCTGATATTCCTGGCTGCTTCTCTGG
CGGTGATGATTATCAGGACGCGATCGAAAGCGTACGTGAAGCGATCGAGGCACACATCGAATTACTGGTTGAAGATGGCG
AGAGCGTTCCCGAAGCAACGACCGTCGAAAACTGGCTATCTGATCCGGAGTACGCCGGTGCGGTATGGGCCCTGGTTGAC
GTGGATATAACACGCCTGATGGGAAAAGCGGAAAAAATCAATGTGACGCTTCCCTCATTGCTGATCCGCCGTATTGATCA
GTTTGTGGCCGCGCATCCAGAATACGGCAGTCGGTCTGGCTTCCTGTCTCGTGTCGCGGCAGATAAAGTAATTGGACGAG
AAAAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References