Detailed information of TA system TA208552

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 984076..984375
• Replicon: chromosome
• Accession: NZ_CP077917
• Organism: Staphylococcus aureus strain 280

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU509_RS05040
• Protein ID: WP_011447039.1
• Coordinates: 984199..984375 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	984076..984131 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU509_RS05000	979407..979667	+	261	WP_001791826.1	hypothetical protein	-
KU509_RS05005	979720..980070	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU509_RS05010	980755..981204	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU509_RS05015	981299..981634	-	336	Protein_953	SH3 domain-containing protein	-
KU509_RS05020	982284..982775	-	492	WP_000919350.1	staphylokinase	-
KU509_RS05025	982966..983721	-	756	WP_064131634.1	CHAP domain-containing protein	-
KU509_RS05030	983733..983987	-	255	WP_000611512.1	phage holin	-
KU509_RS05035	984039..984146	+	108	WP_001791821.1	hypothetical protein	-
-	984068..984207	+	140	NuclAT_0	-	-
-	984068..984207	+	140	NuclAT_0	-	-
-	984068..984207	+	140	NuclAT_0	-	-
-	984068..984207	+	140	NuclAT_0	-	-
-	984076..984131	+	56	-	-	Antitoxin
KU509_RS05040	984199..984375	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU509_RS05045	984525..984821	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU509_RS05050	984879..985166	-	288	WP_001040261.1	hypothetical protein	-
KU509_RS05055	985213..985365	-	153	WP_001153681.1	hypothetical protein	-
KU509_RS05060	985355..989140	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak	979720..1021243	41523

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208552 WP_011447039.1 NZ_CP077917:c984375-984199 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208552 NZ_CP103673:c4586748-4586575 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT208552 NZ_CP077917:984076-984131 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin