Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 886374..886897 Replicon chromosome
Accession NZ_CP077917
Organism Staphylococcus aureus strain 280

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag KU509_RS04605 Protein ID WP_000074045.1
Coordinates 886374..886640 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag KU509_RS04610 Protein ID WP_000587619.1
Coordinates 886640..886897 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU509_RS04585 (881681) 881681..882868 - 1188 WP_225806166.1 MFS transporter -
KU509_RS04590 (883264) 883264..884040 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KU509_RS04595 (884033) 884033..884695 - 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
KU509_RS04600 (884943) 884943..886019 - 1077 WP_001076671.1 M42 family metallopeptidase -
KU509_RS04605 (886374) 886374..886640 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
KU509_RS04610 (886640) 886640..886897 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU509_RS04615 (887257) 887257..887712 + 456 WP_000732079.1 DUF1307 domain-containing protein -
KU509_RS04620 (887880) 887880..889457 - 1578 WP_064626840.1 FMN-binding glutamate synthase family protein -
KU509_RS04625 (889653) 889653..890402 + 750 WP_000072465.1 CPBP family lipoprotein N-acylation protein LnsB -
KU509_RS04630 (890626) 890626..891819 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T208551 WP_000074045.1 NZ_CP077917:c886640-886374 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T208551 NZ_CP103673:c4489788-4489438 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT208551 WP_000587619.1 NZ_CP077917:c886897-886640 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208551 NZ_CP103673:c4490033-4489782 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References