Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 829392..829909 Replicon chromosome
Accession NZ_CP077917
Organism Staphylococcus aureus strain 280

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KU509_RS04330 Protein ID WP_000113262.1
Coordinates 829392..829658 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU509_RS04335 Protein ID WP_000584499.1
Coordinates 829658..829909 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU509_RS04300 (824812) 824812..825348 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KU509_RS04305 (825582) 825582..826406 - 825 WP_000594629.1 formate/nitrite transporter family protein -
KU509_RS04310 (826622) 826622..826807 - 186 WP_000230293.1 hypothetical protein -
KU509_RS04315 (826891) 826891..827358 - 468 WP_000153344.1 SRPBCC domain-containing protein -
KU509_RS04320 (827544) 827544..829097 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU509_RS04325 (829286) 829286..829357 - 72 Protein_815 hypothetical protein -
KU509_RS04330 (829392) 829392..829658 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KU509_RS04335 (829658) 829658..829909 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU509_RS04340 (830074) 830074..830154 - 81 WP_223197974.1 hypothetical protein -
KU509_RS04345 (830182) 830182..830781 - 600 WP_000162810.1 DsbA family protein -
KU509_RS04350 (830800) 830800..831162 - 363 WP_000819840.1 DUF4467 domain-containing protein -
KU509_RS04355 (831417) 831417..832667 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
KU509_RS04360 (832764) 832764..833495 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU509_RS04365 (833492) 833492..834211 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T208548 WP_000113262.1 NZ_CP077917:c829658-829392 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208548 NZ_CP103673:c3988509-3988102 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208548 WP_000584499.1 NZ_CP077917:c829909-829658 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208548 NZ_CP103673:c3988756-3988490 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTATGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References