Detailed information of TA system TA208547

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 569561..569778
• Replicon: chromosome
• Accession: NZ_CP077917
• Organism: Staphylococcus aureus strain 280

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU509_RS02980
• Protein ID: WP_001802298.1
• Coordinates: 569674..569778 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	569561..569616 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU509_RS02955	565755..566420	-	666	WP_001024095.1	SDR family oxidoreductase	-
KU509_RS02960	566572..566892	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU509_RS02965	566894..567874	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU509_RS02970	568140..569231	+	1092	WP_000495683.1	hypothetical protein	-
-	569561..569616	+	56	-	-	Antitoxin
KU509_RS02980	569674..569778	-	105	WP_001802298.1	hypothetical protein	Toxin
KU509_RS02985	569939..570422	-	484	Protein_556	recombinase family protein	-
KU509_RS02990	570465..571601	-	1137	WP_000115564.1	SAP domain-containing protein	-
KU509_RS02995	571890..571982	+	93	WP_001790138.1	hypothetical protein	-
KU509_RS03000	572271..572455	+	185	Protein_559	exotoxin	-
KU509_RS03005	572687..573544	-	858	WP_000370924.1	HAD family hydrolase	-
KU509_RS03010	573612..574394	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208547 WP_001802298.1 NZ_CP077917:c569778-569674 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208547 NZ_CP103673:c3842487-3842152 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT208547 NZ_CP077917:569561-569616 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin