Detailed information of TA system TA208539

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 838175..838474
• Replicon: chromosome
• Accession: NZ_CP077916
• Organism: Staphylococcus aureus strain 281

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU502_RS04265
• Protein ID: WP_011447039.1
• Coordinates: 838298..838474 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	838175..838230 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU502_RS04225	833506..833766	+	261	WP_001791826.1	hypothetical protein	-
KU502_RS04230	833819..834169	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU502_RS04235	834854..835303	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU502_RS04240	835398..835733	-	336	Protein_797	SH3 domain-containing protein	-
KU502_RS04245	836383..836874	-	492	WP_000919350.1	staphylokinase	-
KU502_RS04250	837065..837820	-	756	WP_064131634.1	CHAP domain-containing protein	-
KU502_RS04255	837832..838086	-	255	WP_000611512.1	phage holin	-
KU502_RS04260	838138..838245	+	108	WP_001791821.1	hypothetical protein	-
-	838167..838306	+	140	NuclAT_0	-	-
-	838167..838306	+	140	NuclAT_0	-	-
-	838167..838306	+	140	NuclAT_0	-	-
-	838167..838306	+	140	NuclAT_0	-	-
-	838175..838230	+	56	-	-	Antitoxin
KU502_RS04265	838298..838474	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU502_RS04270	838624..838920	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU502_RS04275	838978..839265	-	288	WP_001040261.1	hypothetical protein	-
KU502_RS04280	839312..839464	-	153	WP_001153681.1	hypothetical protein	-
KU502_RS04285	839454..843239	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak	833819..875342	41523

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208539 WP_011447039.1 NZ_CP077916:c838474-838298 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208539 NZ_CP103673:c1768975-1768319 [Escherichia coli]
ATGGCTTATGATTACAGCGCCAGCCTCAACCCGCAAAAAGCTCTGATCTGGCGTATCGTCCATCGGGACAATATCCCGTG
GATTCTGGATAACGGGCTGCACTGCGGCAACAGTCTGGTGCAGGCGGAAAACTGGATCAATATCGGCAACCCGGAGCTGA
TCGGCAAGCGTGCCGGGCATCCGGTACCTGTCGGAACGGGCGGGACACTGCATGACTATGTGCCGTTTTATTTTACCCCC
TTCTCGCCAATGCTGATGAACATCCACAGCGGGCGCGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGCAACTTGCGAAACGTGGCAGCACACGACGTACCCTTCGTGTTTACCGACAGCCATGCTTACTATAACTGGACCAACT
ACTACACCAGTCTGGATAGTCTGGACCAGATCGACTGGCCCATTTTGCAGGCACGGGACTTTCGCCGCGATCCAGACGAT
CCGGCTAAATTTGAACGCTATCAGGCAGAGGCGCTAATCTGGCAACACTGCCCGATCTCTCTGCTGGATGGGATAATTTG
TTACAGCGAAGAGGTCAGGTTACAATTAGAACAATGGCTGTTTCAGCGTAATCTAACAATGTCCGTTCACACACGGGCTG
GATGGTACTTCTCATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208539 NZ_CP077916:838175-838230 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin