Detailed information of TA system TA208534

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 423660..423877
• Replicon: chromosome
• Accession: NZ_CP077916
• Organism: Staphylococcus aureus strain 281

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU502_RS02205
• Protein ID: WP_001802298.1
• Coordinates: 423773..423877 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	423660..423715 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU502_RS02180	419854..420519	-	666	WP_001024095.1	SDR family oxidoreductase	-
KU502_RS02185	420671..420991	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU502_RS02190	420993..421973	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU502_RS02195	422239..423330	+	1092	WP_000495683.1	hypothetical protein	-
-	423660..423715	+	56	-	-	Antitoxin
KU502_RS02205	423773..423877	-	105	WP_001802298.1	hypothetical protein	Toxin
KU502_RS02210	424038..424521	-	484	Protein_400	recombinase family protein	-
KU502_RS02215	424564..425700	-	1137	WP_000115564.1	SAP domain-containing protein	-
KU502_RS02220	425989..426081	+	93	WP_001790138.1	hypothetical protein	-
KU502_RS02225	426370..426554	+	185	Protein_403	exotoxin	-
KU502_RS02230	426786..427643	-	858	WP_000370924.1	HAD family hydrolase	-
KU502_RS02235	427711..428493	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208534 WP_001802298.1 NZ_CP077916:c423877-423773 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208534 NZ_CP103673:c647233-646769 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208534 NZ_CP077916:423660-423715 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin