Detailed information of TA system TA208525

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2443037..2443315
• Replicon: chromosome
• Accession: NZ_CP077915
• Organism: Staphylococcus aureus strain 282

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU535_RS11830
• Protein ID: WP_001802298.1
• Coordinates: 2443037..2443141 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2443137..2443315 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU535_RS11815 (KU535_11765)	2439833..2440615	+	783	WP_000908174.1	ABC transporter ATP-binding protein	-
KU535_RS11820 (KU535_11770)	2440683..2441540	+	858	WP_000370931.1	HAD family hydrolase	-
KU535_RS11825 (KU535_11775)	2442199..2442357	-	159	WP_001792784.1	hypothetical protein	-
KU535_RS11830 (KU535_11780)	2443037..2443141	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2443137..2443315	-	179	-	-	Antitoxin
KU535_RS11840 (KU535_11785)	2443949..2445595	+	1647	WP_000277718.1	IS1182 family transposase	-
KU535_RS11845 (KU535_11790)	2445624..2446715	-	1092	WP_000495672.1	hypothetical protein	-
KU535_RS13495	2446841..2446975	+	135	WP_263973923.1	hypothetical protein	-
KU535_RS11850 (KU535_11795)	2446981..2447961	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
KU535_RS11855 (KU535_11800)	2447963..2448283	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2443949..2445595	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208525 WP_001802298.1 NZ_CP077915:2443037-2443141 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208525 NZ_CP103672:c4538583-4538206 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT208525 NZ_CP077915:c2443315-2443137 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin