Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2163053..2163237 Replicon chromosome
Accession NZ_CP077915
Organism Staphylococcus aureus strain 282

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KU535_RS10360 Protein ID WP_000482647.1
Coordinates 2163053..2163160 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2163177..2163237 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU535_RS10335 (KU535_10290) 2158425..2158898 + 474 WP_000456492.1 GyrI-like domain-containing protein -
KU535_RS10340 (KU535_10295) 2159021..2160232 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
KU535_RS10345 (KU535_10300) 2160414..2161073 - 660 WP_000831295.1 hypothetical protein -
KU535_RS10350 (KU535_10305) 2161133..2162275 - 1143 WP_001176863.1 glycerate kinase -
KU535_RS10355 (KU535_10310) 2162533..2162919 + 387 WP_000779360.1 flippase GtxA -
KU535_RS10360 (KU535_10315) 2163053..2163160 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2163177..2163237 - 61 - - Antitoxin
KU535_RS10365 (KU535_10320) 2163864..2165627 + 1764 WP_001064836.1 ABC transporter ATP-binding protein -
KU535_RS10370 (KU535_10325) 2165652..2167385 + 1734 WP_000486496.1 ABC transporter ATP-binding protein -
KU535_RS10375 (KU535_10330) 2167616..2167783 + 168 WP_001792506.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T208521 WP_000482647.1 NZ_CP077915:2163053-2163160 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208521 NZ_CP103672:3893550-3893768 [Escherichia coli O25b:H4-ST131]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT208521 NZ_CP077915:c2163237-2163177 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References