Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2131167..2131690 Replicon chromosome
Accession NZ_CP077915
Organism Staphylococcus aureus strain 282

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag KU535_RS10220 Protein ID WP_000074045.1
Coordinates 2131424..2131690 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag KU535_RS10215 Protein ID WP_000587619.1
Coordinates 2131167..2131424 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU535_RS10195 (KU535_10150) 2126247..2127440 + 1194 WP_000675406.1 MFS transporter -
KU535_RS10200 (KU535_10155) 2127664..2128413 - 750 WP_000072464.1 CPBP family lipoprotein N-acylation protein LnsB -
KU535_RS10205 (KU535_10160) 2128608..2130185 + 1578 WP_000143491.1 FMN-binding glutamate synthase family protein -
KU535_RS10210 (KU535_10165) 2130353..2130808 - 456 WP_000732082.1 DUF1307 domain-containing protein -
KU535_RS10215 (KU535_10170) 2131167..2131424 + 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU535_RS10220 (KU535_10175) 2131424..2131690 + 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
KU535_RS10225 (KU535_10180) 2132046..2133122 + 1077 WP_001076673.1 M42 family metallopeptidase -
KU535_RS10230 (KU535_10185) 2133370..2134032 + 663 WP_000923529.1 ATP-binding cassette domain-containing protein -
KU535_RS10235 (KU535_10190) 2134025..2134801 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
KU535_RS10240 (KU535_10195) 2135197..2136384 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T208520 WP_000074045.1 NZ_CP077915:2131424-2131690 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T208520 NZ_CP103672:c3864596-3864294 [Escherichia coli O25b:H4-ST131]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT208520 WP_000587619.1 NZ_CP077915:2131167-2131424 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208520 NZ_CP103672:c3864258-3863917 [Escherichia coli O25b:H4-ST131]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References