Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2617032..2617216 Replicon chromosome
Accession NZ_CP077911
Organism Staphylococcus aureus strain 318

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KU501_RS13200 Protein ID WP_000482647.1
Coordinates 2617109..2617216 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2617032..2617092 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU501_RS13185 2612542..2612709 - 168 Protein_2564 hypothetical protein -
KU501_RS13190 2612940..2614673 - 1734 WP_000486505.1 ABC transporter ATP-binding protein -
KU501_RS13195 2614698..2616461 - 1764 WP_001064829.1 ABC transporter ATP-binding protein -
- 2617032..2617092 + 61 - - Antitoxin
KU501_RS13200 2617109..2617216 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
KU501_RS13205 2617350..2617736 - 387 WP_000779351.1 flippase GtxA -
KU501_RS13210 2618004..2619146 + 1143 WP_001176855.1 glycerate kinase -
KU501_RS13215 2619206..2619865 + 660 WP_000831298.1 membrane protein -
KU501_RS13220 2620047..2621258 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
KU501_RS13225 2621381..2621854 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T208517 WP_000482647.1 NZ_CP077911:c2617216-2617109 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208517 NZ_CP103672:2422212-2422314 [Escherichia coli O25b:H4-ST131]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 61 bp

>AT208517 NZ_CP077911:2617032-2617092 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References