Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2591730..2592247 Replicon chromosome
Accession NZ_CP077911
Organism Staphylococcus aureus strain 318

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag KU501_RS13065 Protein ID WP_000251928.1
Coordinates 2591730..2591996 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag KU501_RS13070 Protein ID WP_000584497.1
Coordinates 2591996..2592247 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU501_RS13040 (2586938) 2586938..2587474 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
KU501_RS13045 (2587942) 2587942..2588766 - 825 WP_000594640.1 formate/nitrite transporter family protein -
KU501_RS13050 (2588969) 2588969..2589151 - 183 WP_000079140.1 hypothetical protein -
KU501_RS13055 (2589237) 2589237..2589704 - 468 WP_000153340.1 SRPBCC domain-containing protein -
KU501_RS13060 (2589890) 2589890..2591437 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU501_RS13065 (2591730) 2591730..2591996 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
KU501_RS13070 (2591996) 2591996..2592247 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU501_RS13075 (2592411) 2592411..2592511 - 101 Protein_2542 hypothetical protein -
KU501_RS13080 (2592518) 2592518..2593117 - 600 WP_000162804.1 DsbA family protein -
KU501_RS13085 (2593136) 2593136..2593498 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KU501_RS13090 (2593753) 2593753..2595003 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
KU501_RS13095 (2595100) 2595100..2595831 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
KU501_RS13100 (2595828) 2595828..2596547 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T208516 WP_000251928.1 NZ_CP077911:c2591996-2591730 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208516 NZ_CP103672:c2043662-2043288 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT208516 WP_000584497.1 NZ_CP077911:c2592247-2591996 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT208516 NZ_CP103672:c2044119-2043751 [Escherichia coli O25b:H4-ST131]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References