Detailed information of TA system TA208509

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2139292..2139591
• Replicon: chromosome
• Accession: NZ_CP077911
• Organism: Staphylococcus aureus strain 318

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU501_RS10615
• Protein ID: WP_011447039.1
• Coordinates: 2139415..2139591 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2139292..2139349 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU501_RS10575	2134671..2134931	+	261	WP_001791826.1	hypothetical protein	-
KU501_RS10580	2134984..2135334	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU501_RS10585	2136019..2136468	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU501_RS10590	2136563..2136898	-	336	Protein_2059	SH3 domain-containing protein	-
KU501_RS10595	2137500..2137991	-	492	WP_000920041.1	staphylokinase	-
KU501_RS10600	2138182..2138937	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU501_RS10605	2138949..2139203	-	255	WP_000611512.1	phage holin	-
KU501_RS10610	2139255..2139362	+	108	WP_031790389.1	hypothetical protein	-
-	2139284..2139423	+	140	NuclAT_0	-	-
-	2139284..2139423	+	140	NuclAT_0	-	-
-	2139284..2139423	+	140	NuclAT_0	-	-
-	2139284..2139423	+	140	NuclAT_0	-	-
-	2139292..2139349	+	58	-	-	Antitoxin
KU501_RS10615	2139415..2139591	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU501_RS10620	2139741..2140037	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU501_RS10625	2140095..2140382	-	288	WP_001040261.1	hypothetical protein	-
KU501_RS10630	2140429..2140581	-	153	WP_001153681.1	hypothetical protein	-
KU501_RS10635	2140571..2144356	-	3786	WP_225798537.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / tsst-1 / groEL	2129210..2204487	75277

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208509 WP_011447039.1 NZ_CP077911:c2139591-2139415 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208509 NZ_CP103672:289193-289720 [Escherichia coli O25b:H4-ST131]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT208509 NZ_CP077911:2139292-2139349 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• PDB: 7NS1

Antitoxin