Detailed information of TA system TA208506

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1938556..1938736
• Replicon: chromosome
• Accession: NZ_CP077911
• Organism: Staphylococcus aureus strain 318

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU501_RS09320
• Protein ID: WP_001801861.1
• Coordinates: 1938556..1938651 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1938679..1938736 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU501_RS09290	1933700..1934326	+	627	WP_000669038.1	hypothetical protein	-
KU501_RS09295	1934367..1934711	+	345	WP_000627550.1	DUF3969 family protein	-
KU501_RS09300	1934809..1935381	+	573	WP_000414222.1	hypothetical protein	-
KU501_RS09305	1935530..1936897	-	1368	WP_001093574.1	FRG domain-containing protein	-
KU501_RS09310	1936897..1937466	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
KU501_RS09315	1937659..1938105	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
KU501_RS09320	1938556..1938651	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1938679..1938736	-	58	-	-	Antitoxin
KU501_RS09325	1938774..1938875	+	102	WP_001791232.1	hypothetical protein	-
KU501_RS09330	1939050..1939493	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
KU501_RS09335	1939493..1939936	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
KU501_RS09340	1939936..1940378	-	443	Protein_1844	DUF1433 domain-containing protein	-
KU501_RS09345	1940903..1943323	+	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208506 WP_001801861.1 NZ_CP077911:1938556-1938651 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208506 NZ_CP103662:25666-25920 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT208506 NZ_CP077911:c1938736-1938679 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin