Detailed information of TA system TA208503

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1605823..1606402
• Replicon: chromosome
• Accession: NZ_CP077911
• Organism: Staphylococcus aureus strain 318

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: KU501_RS07660
• Protein ID: WP_001025401.1
• Coordinates: 1606157..1606402 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1605823..1606188 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU501_RS07620 (1602566)	1602566..1603123	-	558	WP_000645048.1	DUF2815 family protein	-
KU501_RS07625 (1603149)	1603149..1604315	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
KU501_RS07630 (1604312)	1604312..1604674	-	363	WP_000985972.1	hypothetical protein	-
KU501_RS07635 (1604689)	1604689..1605012	-	324	WP_031822699.1	hypothetical protein	-
KU501_RS07640 (1605091)	1605091..1605252	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
KU501_RS07645 (1605265)	1605265..1605528	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
KU501_RS07650 (1605553)	1605553..1605768	-	216	WP_001097552.1	hypothetical protein	-
KU501_RS07655 (1605823)	1605823..1606188	+	366	WP_001128433.1	hypothetical protein	Antitoxin
KU501_RS07660 (1606157)	1606157..1606402	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
KU501_RS07665 (1606469)	1606469..1606849	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
KU501_RS07670 (1606836)	1606836..1607033	-	198	WP_001148860.1	hypothetical protein	-
KU501_RS07675 (1607103)	1607103..1607315	+	213	WP_000362644.1	hypothetical protein	-
KU501_RS07680 (1607356)	1607356..1607505	-	150	WP_000771849.1	hypothetical protein	-
KU501_RS07685 (1607520)	1607520..1607963	-	444	WP_000435357.1	hypothetical protein	-
KU501_RS07690 (1608011)	1608011..1608223	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
KU501_RS07695 (1608375)	1608375..1609106	+	732	WP_000511090.1	XRE family transcriptional regulator	-
KU501_RS07700 (1609177)	1609177..1609359	+	183	WP_000705240.1	hypothetical protein	-
KU501_RS07705 (1609396)	1609396..1609542	+	147	WP_001795334.1	hypothetical protein	-
KU501_RS07710 (1609539)	1609539..1610153	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1565306..1629134	63828

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T208503 WP_001025401.1 NZ_CP077911:c1606402-1606157 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T208503 NZ_CP103658:c108661-108356 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT208503 NZ_CP077911:1605823-1606188 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin