Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1598792..1599215 Replicon chromosome
Accession NZ_CP077911
Organism Staphylococcus aureus strain 318

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag KU501_RS07585 Protein ID WP_001065110.1
Coordinates 1598964..1599215 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag KU501_RS07580 Protein ID WP_000028425.1
Coordinates 1598792..1598974 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU501_RS07540 (1594185) 1594185..1594475 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
KU501_RS07545 (1594609) 1594609..1594713 + 105 WP_015978074.1 hypothetical protein -
KU501_RS07550 (1594816) 1594816..1597263 - 2448 WP_000884879.1 virulence-associated E family protein -
KU501_RS07555 (1597316) 1597316..1597516 - 201 WP_000265258.1 DUF1514 family protein -
KU501_RS07560 (1597584) 1597584..1597736 - 153 WP_000595237.1 transcriptional activator RinB -
KU501_RS07565 (1597729) 1597729..1597965 - 237 WP_000483477.1 hypothetical protein -
KU501_RS07570 (1597990) 1597990..1598226 - 237 WP_000195806.1 DUF1381 domain-containing protein -
KU501_RS07575 (1598263) 1598263..1598799 - 537 WP_000185703.1 dUTPase -
KU501_RS07580 (1598792) 1598792..1598974 - 183 WP_000028425.1 hypothetical protein Antitoxin
KU501_RS07585 (1598964) 1598964..1599215 - 252 WP_001065110.1 DUF1024 family protein Toxin
KU501_RS07590 (1599230) 1599230..1599472 - 243 WP_000132193.1 SAV1978 family virulence-associated passenger protein -
KU501_RS07595 (1599487) 1599487..1599687 - 201 WP_000235324.1 hypothetical protein -
KU501_RS07600 (1599690) 1599690..1599947 - 258 WP_000022730.1 DUF3310 domain-containing protein -
KU501_RS07605 (1599947) 1599947..1600348 - 402 WP_000113974.1 PVL family protein -
KU501_RS07610 (1600348) 1600348..1600533 - 186 WP_001164629.1 DUF3113 family protein -
KU501_RS07615 (1600546) 1600546..1602498 - 1953 WP_225798516.1 DNA polymerase -
KU501_RS07620 (1602566) 1602566..1603123 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1565306..1629134 63828


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T208502 WP_001065110.1 NZ_CP077911:c1599215-1598964 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T208502 NZ_CP103658:24272-24406 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT208502 WP_000028425.1 NZ_CP077911:c1598974-1598792 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT208502 NZ_CP103658:c24227-24167 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References