Detailed information of TA system TA208497

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1582110..1582294
• Replicon: chromosome
• Accession: NZ_CP077908
• Organism: Staphylococcus aureus strain 322

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU527_RS08015
• Protein ID: WP_000482647.1
• Coordinates: 1582187..1582294 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1582110..1582170 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU527_RS07995	1577696..1577863	-	168	WP_031785511.1	hypothetical protein	-
KU527_RS08000	1578094..1579827	-	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
KU527_RS08005	1579876..1581615	-	1740	WP_001064831.1	ABC transporter ATP-binding protein	-
KU527_RS08010	1581993..1582160	-	168	WP_000301894.1	hypothetical protein	-
-	1582110..1582170	+	61	-	-	Antitoxin
KU527_RS08015	1582187..1582294	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU527_RS08020	1582428..1582814	-	387	WP_000779354.1	flippase GtxA	-
KU527_RS08025	1583082..1584224	+	1143	WP_001176860.1	glycerate kinase	-
KU527_RS08030	1584284..1584943	+	660	WP_000831298.1	membrane protein	-
KU527_RS08035	1585123..1586334	+	1212	WP_001191975.1	multidrug effflux MFS transporter	-
KU527_RS08040	1586457..1586930	-	474	WP_000456491.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208497 WP_000482647.1 NZ_CP077908:c1582294-1582187 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208497 NZ_CP103657:c4438524-4438174 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208497 NZ_CP077908:1582110-1582170 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin