Detailed information of TA system TA208493

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1126360..1126667
• Replicon: chromosome
• Accession: NZ_CP077908
• Organism: Staphylococcus aureus strain 322

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU527_RS05600
• Protein ID: WP_011447039.1
• Coordinates: 1126491..1126667 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1126360..1126499 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU527_RS05560 (1121699)	1121699..1121959	+	261	WP_001791826.1	hypothetical protein	-
KU527_RS05565 (1122012)	1122012..1122362	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU527_RS05570 (1123047)	1123047..1123496	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU527_RS05575 (1123591)	1123591..1123926	-	336	Protein_1072	SH3 domain-containing protein	-
KU527_RS05580 (1124576)	1124576..1125067	-	492	WP_000919350.1	staphylokinase	-
KU527_RS05585 (1125258)	1125258..1126013	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU527_RS05590 (1126025)	1126025..1126279	-	255	WP_000611512.1	phage holin	-
KU527_RS05595 (1126331)	1126331..1126438	+	108	WP_001791821.1	hypothetical protein	-
- (1126360)	1126360..1126499	+	140	NuclAT_0	-	Antitoxin
- (1126360)	1126360..1126499	+	140	NuclAT_0	-	Antitoxin
- (1126360)	1126360..1126499	+	140	NuclAT_0	-	Antitoxin
- (1126360)	1126360..1126499	+	140	NuclAT_0	-	Antitoxin
KU527_RS05600 (1126491)	1126491..1126667	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU527_RS05605 (1126817)	1126817..1127113	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU527_RS05610 (1127171)	1127171..1127458	-	288	WP_001040261.1	hypothetical protein	-
KU527_RS05615 (1127505)	1127505..1127657	-	153	WP_001153681.1	hypothetical protein	-
KU527_RS05620 (1127647)	1127647..1131432	-	3786	WP_176330934.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1122012..1175266	53254

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208493 WP_011447039.1 NZ_CP077908:c1126667-1126491 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208493 NZ_CP103657:3738556-3738774 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT208493 NZ_CP077908:1126360-1126499 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin