Detailed information of TA system TA208490

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2609128..2609312
• Replicon: chromosome
• Accession: NZ_CP077899
• Organism: Staphylococcus aureus strain 324

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU505_RS12990
• Protein ID: WP_000482647.1
• Coordinates: 2609205..2609312 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2609128..2609188 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU505_RS12975	2604714..2604881	-	168	WP_031785511.1	hypothetical protein	-
KU505_RS12980	2605112..2606845	-	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
KU505_RS12985	2606894..2608633	-	1740	WP_001064832.1	ABC transporter ATP-binding protein	-
-	2609128..2609188	+	61	-	-	Antitoxin
KU505_RS12990	2609205..2609312	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU505_RS12995	2609446..2609832	-	387	WP_000779354.1	flippase GtxA	-
KU505_RS13000	2610100..2611242	+	1143	WP_001176872.1	glycerate kinase	-
KU505_RS13005	2611302..2611961	+	660	WP_000831298.1	membrane protein	-
KU505_RS13010	2612141..2613352	+	1212	WP_001191973.1	multidrug effflux MFS transporter	-
KU505_RS13015	2613475..2613948	-	474	WP_000456490.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208490 WP_000482647.1 NZ_CP077899:c2609312-2609205 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208490 NZ_CP103657:3042910-3043404 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT208490 NZ_CP077899:2609128-2609188 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin