Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2409015..2409199 Replicon chromosome
Accession NZ_CP077898
Organism Staphylococcus aureus strain 327

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag KU503_RS12160 Protein ID WP_000482647.1
Coordinates 2409092..2409199 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2409015..2409075 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU503_RS12140 2404601..2404768 - 168 WP_031785511.1 hypothetical protein -
KU503_RS12145 2404999..2406732 - 1734 WP_000488492.1 ABC transporter ATP-binding protein -
KU503_RS12150 2406781..2408520 - 1740 WP_001064831.1 ABC transporter ATP-binding protein -
KU503_RS12155 2408898..2409065 - 168 WP_000301894.1 hypothetical protein -
- 2409015..2409075 + 61 - - Antitoxin
KU503_RS12160 2409092..2409199 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
KU503_RS12165 2409333..2409719 - 387 WP_000779354.1 flippase GtxA -
KU503_RS12170 2409987..2411129 + 1143 WP_001176860.1 glycerate kinase -
KU503_RS12175 2411189..2411848 + 660 WP_000831298.1 membrane protein -
KU503_RS12180 2412028..2413239 + 1212 WP_001191975.1 multidrug effflux MFS transporter -
KU503_RS12185 2413362..2413835 - 474 WP_000456491.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T208476 WP_000482647.1 NZ_CP077898:c2409199-2409092 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T208476 NZ_CP103657:166875-167060 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 61 bp

>AT208476 NZ_CP077898:2409015-2409075 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References