Detailed information of TA system TA208472

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1953266..1953573
• Replicon: chromosome
• Accession: NZ_CP077898
• Organism: Staphylococcus aureus strain 327

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU503_RS09740
• Protein ID: WP_011447039.1
• Coordinates: 1953397..1953573 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1953266..1953405 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU503_RS09700 (1948605)	1948605..1948865	+	261	WP_001791826.1	hypothetical protein	-
KU503_RS09705 (1948918)	1948918..1949268	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU503_RS09710 (1949953)	1949953..1950402	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU503_RS09715 (1950497)	1950497..1950832	-	336	Protein_1880	SH3 domain-containing protein	-
KU503_RS09720 (1951482)	1951482..1951973	-	492	WP_000919350.1	staphylokinase	-
KU503_RS09725 (1952164)	1952164..1952919	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU503_RS09730 (1952931)	1952931..1953185	-	255	WP_000611512.1	phage holin	-
KU503_RS09735 (1953237)	1953237..1953344	+	108	WP_001791821.1	hypothetical protein	-
- (1953266)	1953266..1953405	+	140	NuclAT_0	-	Antitoxin
- (1953266)	1953266..1953405	+	140	NuclAT_0	-	Antitoxin
- (1953266)	1953266..1953405	+	140	NuclAT_0	-	Antitoxin
- (1953266)	1953266..1953405	+	140	NuclAT_0	-	Antitoxin
KU503_RS09740 (1953397)	1953397..1953573	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU503_RS09745 (1953723)	1953723..1954019	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU503_RS09750 (1954077)	1954077..1954364	-	288	WP_001040261.1	hypothetical protein	-
KU503_RS09755 (1954411)	1954411..1954563	-	153	WP_001153681.1	hypothetical protein	-
KU503_RS09760 (1954553)	1954553..1958338	-	3786	WP_176330934.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1948918..1999200	50282

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208472 WP_011447039.1 NZ_CP077898:c1953573-1953397 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208472 NZ_CP103654:c4795497-4795213 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT208472 NZ_CP077898:1953266-1953405 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin