Detailed information of TA system TA208467

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1953634..1953941
• Replicon: chromosome
• Accession: NZ_CP077897
• Organism: Staphylococcus aureus strain 328

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU544_RS09765
• Protein ID: WP_011447039.1
• Coordinates: 1953634..1953810 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1953800..1953941 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU544_RS09745	1948869..1952654	+	3786	WP_176330934.1	phage tail spike protein	-
KU544_RS09750	1952644..1952796	+	153	WP_001153681.1	hypothetical protein	-
KU544_RS09755	1952843..1953130	+	288	WP_001040261.1	hypothetical protein	-
KU544_RS09760	1953188..1953484	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU544_RS09765	1953634..1953810	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1953800..1953941	-	142	-	-	Antitoxin
KU544_RS09775	1954022..1954276	+	255	WP_000611512.1	phage holin	-
KU544_RS09780	1954288..1955043	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU544_RS09785	1955234..1955725	+	492	WP_000919350.1	staphylokinase	-
KU544_RS09790	1956375..1956710	+	336	Protein_1919	SH3 domain-containing protein	-
KU544_RS09795	1956805..1957254	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KU544_RS09800	1957939..1958289	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
KU544_RS09805	1958342..1958602	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	1905036..1958289	53253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208467 WP_011447039.1 NZ_CP077897:1953634-1953810 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208467 NZ_CP103654:2460053-2460370 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin

Nucleotide

• Length: 142 bp

>AT208467 NZ_CP077897:c1953941-1953800 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin