Detailed information of TA system TA208460

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1498007..1498191
• Replicon: chromosome
• Accession: NZ_CP077897
• Organism: Staphylococcus aureus strain 328

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: KU544_RS07350
• Protein ID: WP_000482647.1
• Coordinates: 1498007..1498114 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1498131..1498191 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU544_RS07325	1493371..1493844	+	474	WP_000456491.1	GyrI-like domain-containing protein	-
KU544_RS07330	1493967..1495178	-	1212	WP_001191975.1	multidrug effflux MFS transporter	-
KU544_RS07335	1495358..1496017	-	660	WP_000831298.1	membrane protein	-
KU544_RS07340	1496077..1497219	-	1143	WP_001176860.1	glycerate kinase	-
KU544_RS07345	1497487..1497873	+	387	WP_000779354.1	flippase GtxA	-
KU544_RS07350	1498007..1498114	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1498131..1498191	-	61	-	-	Antitoxin
KU544_RS07355	1498141..1498308	+	168	WP_000301894.1	hypothetical protein	-
KU544_RS07360	1498686..1500425	+	1740	WP_001064831.1	ABC transporter ATP-binding protein	-
KU544_RS07365	1500474..1502207	+	1734	WP_000488492.1	ABC transporter ATP-binding protein	-
KU544_RS07370	1502438..1502605	+	168	WP_031785511.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T208460 WP_000482647.1 NZ_CP077897:1498007-1498114 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208460 NZ_CP103646:185718-186023 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208460 NZ_CP077897:c1498191-1498131 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin