Detailed information of TA system TA208453

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1438571..1438751
• Replicon: chromosome
• Accession: NZ_CP077894
• Organism: Staphylococcus aureus strain 329

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU540_RS07350
• Protein ID: WP_001801861.1
• Coordinates: 1438656..1438751 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1438571..1438628 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU540_RS07325	1436316..1436741	+	426	WP_000260278.1	DUF1433 domain-containing protein	-
KU540_RS07330	1436741..1437203	+	463	Protein_1394	DUF1433 domain-containing protein	-
KU540_RS07335	1437203..1437646	+	444	WP_000731441.1	DUF1433 domain-containing protein	-
KU540_RS07340	1438272..1438439	-	168	WP_001268925.1	hypothetical protein	-
KU540_RS07345	1438435..1438533	-	99	Protein_1397	hypothetical protein	-
-	1438571..1438628	+	58	-	-	Antitoxin
KU540_RS07350	1438656..1438751	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
KU540_RS07355	1439203..1439649	+	447	WP_000747807.1	DUF1433 domain-containing protein	-
KU540_RS07360	1440336..1440719	+	384	WP_025174588.1	hypothetical protein	-
KU540_RS07365	1440730..1440906	+	177	WP_000375476.1	hypothetical protein	-
KU540_RS07370	1440908..1441093	+	186	WP_000809681.1	hypothetical protein	-
KU540_RS07375	1441207..1441835	+	629	Protein_1403	ImmA/IrrE family metallo-endopeptidase	-
KU540_RS07380	1442033..1442605	-	573	WP_000414203.1	hypothetical protein	-
KU540_RS07385	1442706..1443047	-	342	WP_060649610.1	DUF3969 family protein	-
KU540_RS07390	1443088..1443714	-	627	WP_000669033.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208453 WP_001801861.1 NZ_CP077894:c1438751-1438656 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208453 NZ_CP103645:3824023-3824301 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT208453 NZ_CP077894:1438571-1438628 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin