Detailed information of TA system TA208451

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 1283116..1283422
• Replicon: chromosome
• Accession: NZ_CP077894
• Organism: Staphylococcus aureus strain 329

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KU540_RS06380
• Protein ID: WP_078159559.1
• Coordinates: 1283116..1283292 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1283282..1283422 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU540_RS06365	1282070..1282237	+	168	WP_000421095.1	hypothetical protein	-
KU540_RS06370	1282281..1282565	+	285	WP_000400415.1	hypothetical protein	-
KU540_RS06375	1282599..1282973	+	375	WP_060649626.1	hypothetical protein	-
KU540_RS06380	1283116..1283292	+	177	WP_078159559.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1283282..1283422	-	141	-	-	Antitoxin
KU540_RS06390	1283503..1283757	+	255	WP_000611512.1	phage holin	-
KU540_RS06395	1283769..1284524	+	756	WP_000861027.1	CHAP domain-containing protein	-
KU540_RS06400	1284715..1285206	+	492	WP_225805878.1	staphylokinase domain-containing protein	-
KU540_RS06405	1285857..1286191	+	335	Protein_1248	SH3 domain-containing protein	-
KU540_RS06410	1286286..1286735	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
KU540_RS06415	1287418..1287768	+	351	WP_225805877.1	complement inhibitor SCIN-A	-
KU540_RS06420	1287821..1288081	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn	1242468..1287768	45300

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6821.39 Da
• Isoelectric Point: 10.6777

>T208451 WP_078159559.1 NZ_CP077894:1283116-1283292 [Staphylococcus aureus]
MDRWWLSEYKEVVPMAALLKSLERRRLMITISTMLQFGLFLIALIGIVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208451 NZ_CP103645:3575944-3576162 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 141 bp

>AT208451 NZ_CP077894:c1283422-1283282 [Staphylococcus aureus]
ATATATAGAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAAG
ATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Antitoxin