Detailed information of TA system TA208437

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 613545..613883
• Replicon: chromosome
• Accession: NZ_CP077893
• Organism: Staphylococcus aureus strain 332

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU542_RS03220
• Protein ID: WP_011447039.1
• Coordinates: 613545..613721 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	613709..613883 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU542_RS03200	608780..612565	+	3786	WP_000582158.1	phage tail spike protein	-
KU542_RS03205	612555..612707	+	153	WP_001153681.1	hypothetical protein	-
KU542_RS03210	612754..613041	+	288	WP_001040261.1	hypothetical protein	-
KU542_RS03215	613099..613395	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU542_RS03220	613545..613721	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	613709..613883	-	175	-	-	Antitoxin
KU542_RS03230	613933..614187	+	255	WP_000611512.1	phage holin	-
KU542_RS03235	614199..614954	+	756	WP_000861038.1	CHAP domain-containing protein	-
KU542_RS03240	615145..615636	+	492	WP_000919350.1	staphylokinase	-
KU542_RS03245	616286..616621	+	336	Protein_636	SH3 domain-containing protein	-
KU542_RS03250	616715..617164	-	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
KU542_RS03255	617846..618196	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
KU542_RS03260	618249..618509	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	562513..618196	55683

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208437 WP_011447039.1 NZ_CP077893:613545-613721 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208437 NZ_CP103645:717151-717447 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT208437 NZ_CP077893:c613883-613709 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin