Detailed information of TA system TA208432

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 439217..439496
• Replicon: chromosome
• Accession: NZ_CP077893
• Organism: Staphylococcus aureus strain 332

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU542_RS02240
• Protein ID: WP_001802298.1
• Coordinates: 439217..439321 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	439317..439496 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU542_RS02210	434601..435383	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
KU542_RS02215	435451..436308	+	858	WP_000370924.1	HAD family hydrolase	-
KU542_RS02220	436540..436724	-	185	Protein_435	exotoxin	-
KU542_RS02225	437013..437105	-	93	WP_001790138.1	hypothetical protein	-
KU542_RS02230	437394..438530	+	1137	WP_000115564.1	SAP domain-containing protein	-
KU542_RS02235	438573..439056	+	484	Protein_438	recombinase family protein	-
KU542_RS02240	439217..439321	+	105	WP_001802298.1	hypothetical protein	Toxin
-	439317..439496	-	180	-	-	Antitoxin
KU542_RS02250	439821..440912	-	1092	WP_000495671.1	lytic regulatory protein	-
KU542_RS02255	441178..442158	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU542_RS02260	442160..442480	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU542_RS02265	442632..443297	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208432 WP_001802298.1 NZ_CP077893:439217-439321 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208432 NZ_CP103642:c4680487-4680116 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGAGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin

Nucleotide

• Length: 180 bp

>AT208432 NZ_CP077893:c439496-439317 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTC
AAAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin