Detailed information of TA system TA208428

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 149793..149977
• Replicon: chromosome
• Accession: NZ_CP077893
• Organism: Staphylococcus aureus strain 332

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: KU542_RS00720
• Protein ID: WP_000482650.1
• Coordinates: 149793..149900 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	149917..149977 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU542_RS00695	145155..145628	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
KU542_RS00700	145751..146962	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU542_RS00705	147144..147803	-	660	WP_000831298.1	membrane protein	-
KU542_RS00710	147863..149005	-	1143	WP_001176863.1	glycerate kinase	-
KU542_RS00715	149273..149659	+	387	WP_000779358.1	flippase GtxA	-
KU542_RS00720	149793..149900	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	149917..149977	-	61	-	-	Antitoxin
KU542_RS00725	150528..152291	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
KU542_RS00730	152316..154049	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
KU542_RS00735	154280..154447	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208428 WP_000482650.1 NZ_CP077893:149793-149900 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208428 NZ_CP103642:c2446502-2446215 [Enterobacter hormaechei]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208428 NZ_CP077893:c149977-149917 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin