Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | SprA2-SprA2AS/- |
| Location | 21967..22151 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP077892 | ||
| Organism | Staphylococcus aureus strain 333 | ||
Toxin (Protein)
| Gene name | SprA2 | Uniprot ID | Q2FVI9 |
| Locus tag | KU539_RS14040 | Protein ID | WP_000482650.1 |
| Coordinates | 22044..22151 (-) | Length | 36 a.a. |
Antitoxin (RNA)
| Gene name | SprA2AS | ||
| Locus tag | - | ||
| Coordinates | 21967..22027 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (17156) | 17156..17216 | - | 61 | NuclAT_2 | - | - |
| - (17156) | 17156..17216 | - | 61 | NuclAT_2 | - | - |
| - (17156) | 17156..17216 | - | 61 | NuclAT_2 | - | - |
| KU539_RS14020 (17317) | 17317..17484 | + | 168 | WP_123986367.1 | hypothetical protein | - |
| KU539_RS14025 (17497) | 17497..17664 | - | 168 | WP_001790576.1 | hypothetical protein | - |
| - (17766) | 17766..17826 | + | 61 | NuclAT_3 | - | - |
| - (17766) | 17766..17826 | + | 61 | NuclAT_3 | - | - |
| - (17766) | 17766..17826 | + | 61 | NuclAT_3 | - | - |
| KU539_RS14030 (17895) | 17895..19625 | - | 1731 | Protein_19 | ABC transporter ATP-binding protein/permease | - |
| KU539_RS14035 (19650) | 19650..21414 | - | 1765 | Protein_20 | ABC transporter ATP-binding protein/permease | - |
| - (21967) | 21967..22027 | + | 61 | NuclAT_1 | - | Antitoxin |
| - (21967) | 21967..22027 | + | 61 | NuclAT_1 | - | Antitoxin |
| - (21967) | 21967..22027 | + | 61 | NuclAT_1 | - | Antitoxin |
| KU539_RS14040 (22044) | 22044..22151 | - | 108 | WP_000482650.1 | type I toxin-antitoxin system Fst family toxin | Toxin |
| KU539_RS14045 (22285) | 22285..22671 | - | 387 | Protein_22 | flippase GtxA | - |
| KU539_RS14050 (22939) | 22939..24082 | + | 1144 | Protein_23 | glycerate kinase | - |
| KU539_RS14055 (24141) | 24141..24233 | + | 93 | Protein_24 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 36 a.a. Molecular weight: 4011.78 Da Isoelectric Point: 11.0582
>T208426 WP_000482650.1 NZ_CP077892:c22151-22044 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK
Download Length: 108 bp
>T208426 NZ_CP103642:1022165-1022533 [Enterobacter hormaechei]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA
Antitoxin
Download Length: 61 bp
>AT208426 NZ_CP077892:21967-22027 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
