Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | SprA2-SprA2AS/- |
| Location | 12826..13010 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP077892 | ||
| Organism | Staphylococcus aureus strain 333 | ||
Toxin (Protein)
| Gene name | SprA2 | Uniprot ID | Q2FVI9 |
| Locus tag | KU539_RS14005 | Protein ID | WP_000482650.1 |
| Coordinates | 12826..12933 (+) | Length | 36 a.a. |
Antitoxin (RNA)
| Gene name | SprA2AS | ||
| Locus tag | - | ||
| Coordinates | 12950..13010 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU539_RS13980 (8188) | 8188..8661 | + | 474 | WP_000456489.1 | GyrI-like domain-containing protein | - |
| KU539_RS13985 (8784) | 8784..9995 | - | 1212 | WP_001192075.1 | multidrug effflux MFS transporter | - |
| KU539_RS13990 (10177) | 10177..10836 | - | 660 | WP_000831298.1 | membrane protein | - |
| KU539_RS13995 (10896) | 10896..12038 | - | 1143 | WP_001176863.1 | glycerate kinase | - |
| KU539_RS14000 (12306) | 12306..12692 | + | 387 | WP_000779358.1 | flippase GtxA | - |
| KU539_RS14005 (12826) | 12826..12933 | + | 108 | WP_000482650.1 | type I toxin-antitoxin system Fst family toxin | Toxin |
| - (12950) | 12950..13010 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (12950) | 12950..13010 | - | 61 | NuclAT_0 | - | Antitoxin |
| - (12950) | 12950..13010 | - | 61 | NuclAT_0 | - | Antitoxin |
| KU539_RS14010 (13561) | 13561..15325 | + | 1765 | Protein_15 | ABC transporter ATP-binding protein/permease | - |
| KU539_RS14015 (15350) | 15350..17086 | + | 1737 | Protein_16 | ABC transporter ATP-binding protein/permease | - |
| - (17156) | 17156..17216 | - | 61 | NuclAT_2 | - | - |
| - (17156) | 17156..17216 | - | 61 | NuclAT_2 | - | - |
| - (17156) | 17156..17216 | - | 61 | NuclAT_2 | - | - |
| KU539_RS14020 (17317) | 17317..17484 | + | 168 | WP_123986367.1 | hypothetical protein | - |
| KU539_RS14025 (17497) | 17497..17664 | - | 168 | WP_001790576.1 | hypothetical protein | - |
| - (17766) | 17766..17826 | + | 61 | NuclAT_3 | - | - |
| - (17766) | 17766..17826 | + | 61 | NuclAT_3 | - | - |
| - (17766) | 17766..17826 | + | 61 | NuclAT_3 | - | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 36 a.a. Molecular weight: 4011.78 Da Isoelectric Point: 11.0582
>T208423 WP_000482650.1 NZ_CP077892:12826-12933 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK
Download Length: 108 bp
>T208423 NZ_CP103639:c4696227-4695907 [Klebsiella aerogenes]
ATGAAATTTCTACCTGCAACAAATATGCGGGCGGCGAAGCCATGCCAGTCGCCTGTGACTATCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAGCATTATGGCCTGACACTCAACGACACACCATTTAGTGATGAGACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCTGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTACCGATCGCAGAGGGTTT
AACTGGCAGGAGCAATCACCTTATCTTCAAGTTGTAGATATCCTGCAGGCACGACAAGCGATTGGCAGCTCAAGTAAGTA
A
ATGAAATTTCTACCTGCAACAAATATGCGGGCGGCGAAGCCATGCCAGTCGCCTGTGACTATCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAGCATTATGGCCTGACACTCAACGACACACCATTTAGTGATGAGACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCTGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTACCGATCGCAGAGGGTTT
AACTGGCAGGAGCAATCACCTTATCTTCAAGTTGTAGATATCCTGCAGGCACGACAAGCGATTGGCAGCTCAAGTAAGTA
A
Antitoxin
Download Length: 61 bp
>AT208423 NZ_CP077892:c13010-12950 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
