Detailed information of TA system TA208416

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2379595..2379894
• Replicon: chromosome
• Accession: NZ_CP077889
• Organism: Staphylococcus aureus strain 333

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU539_RS11610
• Protein ID: WP_011447039.1
• Coordinates: 2379718..2379894 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2379595..2379650 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU539_RS11570	2374930..2375190	+	261	WP_001791826.1	hypothetical protein	-
KU539_RS11575	2375243..2375593	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
KU539_RS11580	2376275..2376724	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
KU539_RS11585	2376818..2377153	-	336	Protein_2250	SH3 domain-containing protein	-
KU539_RS11590	2377803..2378294	-	492	WP_000919350.1	staphylokinase	-
KU539_RS11595	2378485..2379240	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU539_RS11600	2379252..2379506	-	255	WP_000611512.1	phage holin	-
KU539_RS11605	2379558..2379665	+	108	WP_001791821.1	hypothetical protein	-
-	2379587..2379726	+	140	NuclAT_0	-	-
-	2379587..2379726	+	140	NuclAT_0	-	-
-	2379587..2379726	+	140	NuclAT_0	-	-
-	2379587..2379726	+	140	NuclAT_0	-	-
-	2379595..2379650	+	56	-	-	Antitoxin
KU539_RS11610	2379718..2379894	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU539_RS11615	2380044..2380340	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU539_RS11620	2380398..2380685	-	288	WP_001040261.1	hypothetical protein	-
KU539_RS11625	2380732..2380884	-	153	WP_001153681.1	hypothetical protein	-
KU539_RS11630	2380874..2384659	-	3786	WP_000582158.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2375243..2430926	55683

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208416 WP_011447039.1 NZ_CP077889:c2379894-2379718 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208416 NZ_CP103635:c5304583-5304200 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208416 NZ_CP077889:2379595-2379650 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin