Detailed information of TA system TA208413

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2218622..2218804
• Replicon: chromosome
• Accession: NZ_CP077889
• Organism: Staphylococcus aureus strain 333

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: KU539_RS10630
• Protein ID: WP_001801861.1
• Coordinates: 2218622..2218717 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2218745..2218804 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU539_RS10590	2214282..2214908	+	627	WP_000669046.1	hypothetical protein	-
KU539_RS10595	2214949..2215293	+	345	WP_000627551.1	DUF3969 family protein	-
KU539_RS10600	2215391..2215942	+	552	WP_000414205.1	hypothetical protein	-
KU539_RS10605	2216160..2216801	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
KU539_RS10610	2216915..2217100	-	186	WP_000809857.1	hypothetical protein	-
KU539_RS10615	2217102..2217278	-	177	WP_000375476.1	hypothetical protein	-
KU539_RS10620	2217289..2217672	-	384	WP_000070811.1	hypothetical protein	-
KU539_RS10625	2218276..2218419	-	144	WP_001549059.1	transposase	-
KU539_RS10630	2218622..2218717	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2218745..2218804	-	60	-	-	Antitoxin
KU539_RS10635	2218840..2218941	+	102	WP_001791893.1	hypothetical protein	-
KU539_RS10640	2218919..2219095	-	177	Protein_2100	transposase	-
KU539_RS10645	2219289..2219666	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2211722..2238720	26998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T208413 WP_001801861.1 NZ_CP077889:2218622-2218717 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T208413 NZ_CP103635:c4727384-4727043 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT208413 NZ_CP077889:c2218804-2218745 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin