Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 72534..73051 Replicon chromosome
Accession NZ_CP077889
Organism Staphylococcus aureus strain 333

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag KU539_RS00360 Protein ID WP_000113262.1
Coordinates 72534..72800 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag KU539_RS00365 Protein ID WP_000584499.1
Coordinates 72800..73051 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU539_RS00330 (67960) 67960..68496 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
KU539_RS00335 (68729) 68729..69553 - 825 WP_000572040.1 formate/nitrite transporter family protein -
KU539_RS00340 (69770) 69770..69952 - 183 WP_000230294.1 hypothetical protein -
KU539_RS00345 (70036) 70036..70503 - 468 WP_000153344.1 SRPBCC domain-containing protein -
KU539_RS00350 (70689) 70689..72239 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
KU539_RS00355 (72428) 72428..72499 - 72 Protein_70 hypothetical protein -
KU539_RS00360 (72534) 72534..72800 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
KU539_RS00365 (72800) 72800..73051 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU539_RS00370 (73216) 73216..73317 - 102 WP_001791744.1 hypothetical protein -
KU539_RS00375 (73324) 73324..73923 - 600 WP_000162813.1 DsbA family protein -
KU539_RS00380 (73942) 73942..74304 - 363 WP_000819843.1 DUF4467 domain-containing protein -
KU539_RS00385 (74559) 74559..75809 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
KU539_RS00390 (75906) 75906..76637 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
KU539_RS00395 (76634) 76634..77353 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T208409 WP_000113262.1 NZ_CP077889:c72800-72534 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T208409 NZ_CP103635:2449466-2449783 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT208409 WP_000584499.1 NZ_CP077889:c73051-72800 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT208409 NZ_CP103635:2449859-2450155 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References