Detailed information of TA system TA208406

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 674976..675160
• Replicon: chromosome
• Accession: NZ_CP077888
• Organism: Staphylococcus aureus strain 334

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: KU519_RS03745
• Protein ID: WP_000482650.1
• Coordinates: 675053..675160 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	674976..675036 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU519_RS03730	670506..670673	-	168	WP_001790576.1	hypothetical protein	-
KU519_RS03735	670904..672637	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
KU519_RS03740	672662..674425	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	674976..675036	+	61	-	-	Antitoxin
KU519_RS03745	675053..675160	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU519_RS03750	675294..675680	-	387	WP_000779358.1	flippase GtxA	-
KU519_RS03755	675948..677090	+	1143	WP_001176863.1	glycerate kinase	-
KU519_RS03760	677150..677809	+	660	WP_000831298.1	membrane protein	-
KU519_RS03765	677991..679202	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU519_RS03770	679325..679798	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208406 WP_000482650.1 NZ_CP077888:c675160-675053 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208406 NZ_CP103635:349413-349760 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT208406 NZ_CP077888:674976-675036 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin