Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 649624..650141 | Replicon | chromosome |
| Accession | NZ_CP077888 | ||
| Organism | Staphylococcus aureus strain 334 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | KU519_RS03610 | Protein ID | WP_000113262.1 |
| Coordinates | 649624..649890 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | KU519_RS03615 | Protein ID | WP_000584499.1 |
| Coordinates | 649890..650141 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KU519_RS03580 (645050) | 645050..645586 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| KU519_RS03585 (645819) | 645819..646643 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| KU519_RS03590 (646860) | 646860..647042 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| KU519_RS03595 (647126) | 647126..647593 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| KU519_RS03600 (647779) | 647779..649329 | - | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| KU519_RS03605 (649518) | 649518..649589 | - | 72 | Protein_668 | hypothetical protein | - |
| KU519_RS03610 (649624) | 649624..649890 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| KU519_RS03615 (649890) | 649890..650141 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KU519_RS03620 (650306) | 650306..650407 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| KU519_RS03625 (650414) | 650414..651013 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| KU519_RS03630 (651032) | 651032..651394 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| KU519_RS03635 (651649) | 651649..652899 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| KU519_RS03640 (652996) | 652996..653727 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| KU519_RS03645 (653724) | 653724..654443 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T208405 WP_000113262.1 NZ_CP077888:c649890-649624 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T208405 NZ_CP103635:323452-323820 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT208405 WP_000584499.1 NZ_CP077888:c650141-649890 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT208405 NZ_CP103635:323234-323455 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|