Detailed information of TA system TA208404

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 385519..385736
• Replicon: chromosome
• Accession: NZ_CP077888
• Organism: Staphylococcus aureus strain 334

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: KU519_RS02225
• Protein ID: WP_001802298.1
• Coordinates: 385632..385736 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	385519..385574 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU519_RS02200	381656..382321	-	666	WP_001024094.1	SDR family oxidoreductase	-
KU519_RS02205	382473..382793	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
KU519_RS02210	382795..383775	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
KU519_RS02215	384041..385132	+	1092	WP_000495671.1	lytic regulatory protein	-
-	385519..385574	+	56	-	-	Antitoxin
KU519_RS02225	385632..385736	-	105	WP_001802298.1	hypothetical protein	Toxin
KU519_RS02230	385897..386380	-	484	Protein_401	recombinase family protein	-
KU519_RS02235	386423..387559	-	1137	WP_000115564.1	SAP domain-containing protein	-
KU519_RS02240	387848..387940	+	93	WP_001790138.1	hypothetical protein	-
KU519_RS02245	388229..388413	+	185	Protein_404	exotoxin	-
KU519_RS02250	388645..389502	-	858	WP_000370924.1	HAD family hydrolase	-
KU519_RS02255	389570..390352	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T208404 WP_001802298.1 NZ_CP077888:c385736-385632 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T208404 NZ_CP103634:149843-150148 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208404 NZ_CP077888:385519-385574 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin