Detailed information of TA system TA208398

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 211109..211408
• Replicon: chromosome
• Accession: NZ_CP077888
• Organism: Staphylococcus aureus strain 334

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KU519_RS01240
• Protein ID: WP_011447039.1
• Coordinates: 211232..211408 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	211109..211164 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU519_RS01200	206444..206704	+	261	WP_001791826.1	hypothetical protein	-
KU519_RS01205	206757..207107	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
KU519_RS01210	207789..208238	+	450	WP_000727651.1	chemotaxis-inhibiting protein CHIPS	-
KU519_RS01215	208332..208667	-	336	Protein_203	SH3 domain-containing protein	-
KU519_RS01220	209317..209808	-	492	WP_000919350.1	staphylokinase	-
KU519_RS01225	209999..210754	-	756	WP_000861038.1	CHAP domain-containing protein	-
KU519_RS01230	210766..211020	-	255	WP_000611512.1	phage holin	-
KU519_RS01235	211072..211179	+	108	WP_001791821.1	hypothetical protein	-
-	211101..211240	+	140	NuclAT_0	-	-
-	211101..211240	+	140	NuclAT_0	-	-
-	211101..211240	+	140	NuclAT_0	-	-
-	211101..211240	+	140	NuclAT_0	-	-
-	211109..211164	+	56	-	-	Antitoxin
KU519_RS01240	211232..211408	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KU519_RS01245	211558..211854	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KU519_RS01250	211912..212199	-	288	WP_001040261.1	hypothetical protein	-
KU519_RS01255	212246..212398	-	153	WP_001153681.1	hypothetical protein	-
KU519_RS01260	212388..216173	-	3786	WP_000582158.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL	202940..265498	62558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T208398 WP_011447039.1 NZ_CP077888:c211408-211232 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T208398 NZ_CP103633:c4523968-4523678 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT208398 NZ_CP077888:211109-211164 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin