Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2265563..2266086 Replicon chromosome
Accession NZ_CP077885
Organism Staphylococcus aureus strain 355

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag KU507_RS11670 Protein ID WP_000074048.1
Coordinates 2265563..2265829 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KU507_RS11675 Protein ID WP_000587616.1
Coordinates 2265829..2266086 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KU507_RS11650 (2260871) 2260871..2262058 - 1188 WP_000026194.1 MFS transporter -
KU507_RS11655 (2262454) 2262454..2263230 - 777 WP_050956485.1 iron export ABC transporter permease subunit FetB -
KU507_RS11660 (2263223) 2263223..2263885 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
KU507_RS11665 (2264132) 2264132..2265208 - 1077 WP_001076671.1 M42 family metallopeptidase -
KU507_RS11670 (2265563) 2265563..2265829 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
KU507_RS11675 (2265829) 2265829..2266086 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KU507_RS11680 (2266445) 2266445..2266900 + 456 WP_000732082.1 DUF1307 domain-containing protein -
KU507_RS11685 (2267068) 2267068..2268645 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
KU507_RS11690 (2268840) 2268840..2269589 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
KU507_RS11695 (2269813) 2269813..2271006 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T208394 WP_000074048.1 NZ_CP077885:c2265829-2265563 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T208394 NZ_CP103633:3811480-3811698 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT208394 WP_000587616.1 NZ_CP077885:c2266086-2265829 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT208394 NZ_CP103633:3811080-3811454 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References