Detailed information of TA system TA208392

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2234066..2234250
• Replicon: chromosome
• Accession: NZ_CP077885
• Organism: Staphylococcus aureus strain 355

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: KU507_RS11530
• Protein ID: WP_000482650.1
• Coordinates: 2234143..2234250 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2234066..2234126 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KU507_RS11515	2229596..2229763	-	168	WP_001790576.1	hypothetical protein	-
KU507_RS11520	2229994..2231727	-	1734	WP_031833708.1	ABC transporter ATP-binding protein	-
KU507_RS11525	2231752..2233515	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2234066..2234126	+	61	-	-	Antitoxin
KU507_RS11530	2234143..2234250	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
KU507_RS11535	2234383..2234769	-	387	WP_000779358.1	flippase GtxA	-
KU507_RS11540	2235037..2236179	+	1143	WP_001176863.1	glycerate kinase	-
KU507_RS11545	2236239..2236898	+	660	WP_000831298.1	membrane protein	-
KU507_RS11550	2237080..2238291	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
KU507_RS11555	2238414..2238887	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T208392 WP_000482650.1 NZ_CP077885:c2234250-2234143 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T208392 NZ_CP103633:3100949-3101443 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT208392 NZ_CP077885:2234066-2234126 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin